Research

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Clinical outcomes reported for solid tumor adoptive cell therapy have been inadequate compared to liquid cancers. To improve therapeutic efficacy and treatment cost-effectiveness which depend on long-term clinical outcomes, T-cell manufacturing methods require development. Standard, non-optimal, formulae are currently used in the manufacture and a knowledge gap exists for which factors are required to produce clinically optimal T cells in an artificial in vitro expansion versus a successful physiological in vivo T cell response. Large-scale testing is required to identify these factors.  

 

By merging automated high-throughput screening technologies with clinical T-cell manufacturing and the access to innovative reagents, The CellFit Project seeks to provide significantly improved cellular products
(more active and in vivo persistent) and processes (higher yields, more streamlined). Although high-throughput screening approaches are used to identify and select targets or antigens in T-cell therapy, no one is currently using these techniques to screen culture conditions to advance the T-cell manufacturing process. 

Primary Objective

The primary objective of CellFit is to define optimal growth conditions for improved manufacturing of therapeutically active, adapted therapeutic T cells required for solid tumour treatment. CellFit’s aim is to provide access to this technology to drug developers to enable their successful translation and commercialization of products which in turn, will benefit a larger number of patients.  This will be accomplished by developing novel screening methods and translate these to clinical practice, taking into account cGMP manufacturing requirements and economic practicalities. 

 

Secondary Objective

The secondary objectives of this project are to establish efficient screening methods to identify optimal growth conditions for T cells, evaluate the patient-specific variation in growth conditions that should be used for T cell expansion, translate the identified protocols into clinical use for adoptive T-cell therapy using relevant patient material, expand the use of the established screening platform to other applications in immunotherapy such as drug combinations (epigenetic modulators, checkpoint inhibitors) and their effects on T cells, and to perform this research actively integrating Responsible Research and Innovation (RRI) principles. 

About T cells (use as marker now, will consult with Else Marit) 

Source:  Definition of T cell – NCI Dictionary of Cancer Terms – NCI 

A type of white blood cell. T cells are part of the immune system and develop from stem cells in the bone marrow. They help protect the body from infection and may help fight cancer. Also called T lymphocyte and thymocyte. 

Key Questions and Hypothesis

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Theoretical Approach and Methodology

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Expected Outcome

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John Doe

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Learn more about ongoing research and scientific publications here: